01/18/2016
APTSol Team is always at the forefront in research in the field of pharmaceutical technology. As evidence here is the recent study published in the leading journal "International Journal of Pharmaceutics" entitled "Self-emulsifying excipient platform for improving technological properties of alginate-hydroxypropylcellulose pellets"
Below is a brief summary of the work done.
Pellets based on alginate or alginate/hydroxypropylcellulose mixture or alginate/pectin mixture containing an active principle model (ibuprofen) were produced with the technique of inotropic gelation. The drug was dispersed in the polymer solution or dissolved in a self-emulsifier phase that can improve the biopharmaceutical properties of the pellets. There were obtained 8 different formulations that were characterized with sophisticated techniques (DSC, dissolution assay). The study has provided interesting results: the formulations comprise alginate and hydroxypropyl cellulose and containing the drug dissolved in the self-emulsifying phase have shown the ability to release the active ingredient in a controlled manner. A further demonstration of how, thanks to a proper formulation study, it is possible to obtain pharmaceutical forms with improved technological capabilities and biopharmaceutical.
